The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

Names of Reporting Persons.

New Leaf Ventures III, L.P. (“NLV III”)

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only

Source of Funds (See Instructions)

WC

Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)

☐

Citizenship or Place of Organization

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With

Sole Voting Power

1,908,048 shares, except that (a) New Leaf Venture Associates III, L.P. (“NLV Associates III”), the sole general partner of NLV III, may be deemed to have sole power to vote such shares, (b) New Leaf Venture Management III, L.L.C. (“NLV Management III”), the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares, and (c) Liam Ratcliffe, a member of the Issuer’s board of directors (“Ratcliffe”), Ronald M. Hunt (“Hunt”) and Vijay K. Lathi (“Lathi”), the managers of NLV Management III, may each be deemed to have shared power to vote such shares.

Shared Voting Power

See response to row 7.

Sole Dispositive Power

1,908,048 shares, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares, and (c) Ratcliffe, a member of the Issuer’s board of directors, Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares.

Shared Dispositive Power

See response to row 9.

Aggregate Amount Beneficially Owned by Each Reporting Person

1,908,048

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

☐

Percent of Class Represented by Amount in Row (11)

5.9%¹

Type of Reporting Person (See Instructions)

PN

Based on 32,158,748 shares of the Issuer’s Common Stock outstanding following the completion of its initial public offering and as reported on the Issuer’s Prospectus filed pursuant to Rule 424(b)(4) (File No. 333-227112) with the United States Securities and Exchange Commission on September 27, 2018.

Names of Reporting Persons.

New Leaf Venture Associates III, L.P.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only

Source of Funds (See Instructions)

AF

Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)

☐

Citizenship or Place of Organization

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With

Sole Voting Power

1,908,048 shares, all of which are owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares, and (c) Ratcliffe, a member of the Issuer’s board of directors, Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares.

Shared Voting Power

See response to row 7.

Sole Dispositive Power

1,908,048 shares, all of which are owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares, and (c) Ratcliffe, a member of the Issuer’s board of directors, Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares.

Shared Dispositive Power

See response to Row 9.

Aggregate Amount Beneficially Owned by Each Reporting Person

1,908,048

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

☐

Percent of Class Represented by Amount in Row (11)

5.9%¹

Type of Reporting Person (See Instructions)

PN

Names of Reporting Persons.

New Leaf Venture Management III, L.L.C.

Check the Appropriate Box if a Member of a Group (See Instructions)

(a)  ☐        (b)  ☒

SEC Use Only

Source of Funds (See Instructions)

AF

Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e)

☐

Citizenship or Place of Organization

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With

Sole Voting Power

1,908,048 shares, all of which are directly owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote all of the shares directly owned by NLV III, and (c) Ratcliffe, a member of the Issuer’s board of directors, Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote all of such shares.

Shared Voting Power

See response to row 7.

Sole Dispositive Power

1,908,048 shares, all of which are directly owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of the shares directly owned by NLV III, and (c) Ratcliffe, a member of the Issuer’s board of directors, Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of all of such shares.

Shared Dispositive Power

See response to row 9.

Aggregate Amount Beneficially Owned by Each Reporting Person

1,908,048

Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)

☐

Percent of Class Represented by Amount in Row (11)

5.9%¹

Type of Reporting Person (See Instructions)

OO

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

New Leaf Biopharma Opportunities II, L.P. (“Biopharma II”)

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

375,000 shares, except that (a) New Leaf BPO Associates II, L.P. (“NLBA II”), the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) New Leaf BPO Management II, L.L.C. (“NLB Management II”), the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Isaac Manke (“Manke”), the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

SHARED VOTING POWER

See response to row 5.

SOLE DISPOSITIVE POWER

375,000 shares, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

SHARED DISPOSITIVE POWER

See response to row 7.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

375,000 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

1.2%¹

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

PN

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

New Leaf BPO Associates II, L.P.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

375,000 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

SHARED VOTING POWER

See response to row 5.

SOLE DISPOSITIVE POWER

375,000 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

SHARED DISPOSITIVE POWER

See response to row 7.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

375,000 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

1.2%¹

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

PN

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

New Leaf BPO Management II, L.L.C.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

375,000 shares, all of which are owned by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

SHARED VOTING POWER

See response to row 5.

SOLE DISPOSITIVE POWER

375,000 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

SHARED DISPOSITIVE POWER

See response to row 7.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

375,000 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

1.2%¹

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

OO

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Ronald M. Hunt

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

United States citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

See response to row 6.

SHARED VOTING POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares owned by NLV III, and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares owned by Biopharma II.

SOLE DISPOSITIVE POWER

See response to row 8.

SHARED DISPOSITIVE POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares owned by NLV III, and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares owned by Biopharma II.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,283,048 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

7.1¹%

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

IN

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Vijay K. Lathi

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

United States citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

See response to row 6.

SHARED VOTING POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares owned by NLV III, and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares owned by Biopharma II.

SOLE DISPOSITIVE POWER

See response to row 8.

SHARED DISPOSITIVE POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares owned by NLV III and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares owned by Biopharma II.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,283,048 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

7.1¹%

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

IN

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Liam T. Ratcliffe

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

United States citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

See response to row 6.

SHARED VOTING POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares owned by NLV III, and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares owned by Biopharma II.

SOLE DISPOSITIVE POWER

See response to row 8.

SHARED DISPOSITIVE POWER

2,283,048 shares, of which (a) 1,908,048 are owned directly by NLV III and (b) 375,000 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares directly owned by NLV III, (v) Ratcliffe, a member of the Issuer’s board of directors, Hunt, and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares owned by NLV III, and (vi) Ratcliffe, a member of the Issuer’s board of directors, Hunt, Lathi, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares owned by Biopharma II.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

2,283,048 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

7.1¹%

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

IN

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

Isaac Manke

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

(a)  ☐        (b)  ☒

SEC USE ONLY

CITIZENSHIP OR PLACE OF ORGANIZATION

United States citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

SOLE VOTING POWER

See response to row 6.

SHARED VOTING POWER

375,000 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Hunt, Lathi, Ratcliffe, a member of the Issuer’s board of directors, and Manke, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

SOLE DISPOSITIVE POWER

See response to row 8.

SHARED DISPOSITIVE POWER

375,000 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Hunt, Lathi, Ratcliffe, a member of the Issuer’s board of directors, and Manke, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

375,000 shares

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

☐

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

1.1¹%

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

IN

Name of Issuer:

Address of Issuer’s Principal Executive Offices:

Name of Persons Filing:

Address of Principal Business Office or, if None, Residence:

Citizenship:

Title of Class of Securities:

CUSIP Number:

If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:

Ownership.

Amount beneficially owned:

See line 9 of cover sheets. NLV III is the record owner of 1,908,048 shares of Common Stock of the Issuer (the “NLV III Shares”). As the sole general partner of NLV III, NLV Associates III may be deemed to own beneficially the NLV III shares. As the sole general partner of NLV Associates III and ultimate general partner of NLV III, NLV Management III may be deemed to own beneficially the NLV III shares. As the individual managers of NLV Management III, each of Ratcliffe, Hunt and Lathi may be deemed to own beneficially the NLV III Shares. Biopharma II is the record owner of the 375,000 shares of Common Stock (the “Biopharma II Shares”). As the sole general partner of Biopharma II, NLBA II may be deemed to own beneficially the Biopharma II Shares. As the sole general partner of NLBA II and ultimate general partner of Biopharma II, NLB Management II may be deemed to own beneficially the Biopharma II Shares. As the individual managers of NLB Management II, each of Ratcliffe, Hunt, Lathi and Manke also may be deemed to own beneficially the Biopharma II Shares.

Percent of class:

See Line 11 of cover sheets. The percentages set forth on the cover sheet for each Reporting Person are calculated based on 32,158,748 shares of Common Stock reported by the Issuer to be outstanding as of following the completion of the Issuer’s initial public offering and as reported in its Prospectus filed pursuant to Rule 424(b)(4) (File No. 333-227112) with the United States Securities and Exchange Commission on September 27, 2018.

Number of shares as to which the person has:

Sole power to vote or to direct the vote: see line 5 of cover sheets.

Shared power to vote or to direct the vote: see line 6 of cover sheets.

Sole power to dispose or to direct the disposition of: see line 7 of cover sheets.

Shared power to dispose or to direct the disposition of: see line 8 of cover sheets.

Ownership of Five Percent or Less of a Class.

Ownership of More than Five Percent on Behalf of Another Person.

Identification and Classification of the Subsidiary which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Identification and Classification of Members of the Group.

Notice of Dissolution of Group.

Certification.

This Schedule 13G was executed by Craig L. Slutzkin on behalf of the individuals listed above pursuant to Powers of Attorney. Note that copies of the applicable Powers of Attorney are already on file with the appropriate agencies.

This Schedule 13G was executed by Craig L. Slutzkin on behalf of the individuals listed above pursuant to Powers of Attorney. Note that copies of the applicable Powers of Attorney are already on file with the appropriate agencies.