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Important Notice Regarding the Availability of Proxy Materials for the Shareholder Meeting to Be Held on June 8, 2021 D51559-P50789 Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 25, 2021. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. To view the proxy materials and to vote, visit  Control # Vote in Advance of the Meeting Vote by June 7, 2021 11:59 PM ET Visit Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* Vote on June 8, 2021 8:30 AM ET Visit *Please check the meeting materials for any special requirements for meeting attendance. V1 Your Vote Counts! ARVINAS, INC. 2021 Annual Meeting Vote by June 7, 2021 11:59 PM ET To Be Held on June 8, 2021 8:30 AM ET  Virtual Meeting Site: ARVINAS, INC. 5 SCIENCE PARK 395 WINCHESTER AVE. NEW HAVEN, CT 06511  ARVINAS, INC. 5 SCIENCE PARK 395 WINCHESTER AVE. NEW HAVEN, CT 06511  You invested in ARVINAS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting.






Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items 1. Election of Directors  Nominees:  01) Wendy Dixon, Ph.D.  02) Edward Kennedy, Jr.  03) Bradley Margus  04) Briggs Morrison, M.D. For 2. To approve, on an advisory basis, the Company’s named executive compensation. For 3. To approve, on an advisory basis, the frequency of the advisory vote on executive compensation. Year 1 4. Ratification of the appointment of Deloitte & Touche LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2021. For NOTE: The proxies are authorized to vote, in their discretion, upon such other business as may properly come before the annual meeting or any adjournment or postponement of the annual meeting. Prefer to receive an email instead? While voting on, be sure to click “Sign up for E-delivery”. D51560-P50789