The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

  NAMES OF REPORTING PERSONS

  New Leaf Ventures III, L.P. (“NLV III”)

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With

  SOLE VOTING POWER

1,080,546 shares, except that (a) New Leaf Venture Associates III, L.P. (“NLV Associates III”), the sole general partner of NLV III, may be deemed to have sole power to vote such shares, (b) New Leaf Venture Management III, L.L.C. (“NLV Management III”), the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares, and (c) Ronald M. Hunt (“Hunt”) and Vijay K. Lathi (“Lathi”), the managers of NLV Management III, may each be deemed to have shared power to vote such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

1,080,546 shares, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares, and (c) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares.

  SHARED DISPOSITIVE POWER

  See response to row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  1,080,546 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  2.0% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  PN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in its Form 10-Q for the quarter ended September 30, 2021, filed with the United States Securities and Exchange Commission on November 3, 2021 (the “Form 10-Q”).

  NAMES OF REPORTING PERSONS

  New Leaf Venture Associates III, L.P.

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With

  SOLE VOTING POWER

1,080,546 shares, all of which are owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares, and (c) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

1,080,546 shares, all of which are owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares, and (c) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares.

  SHARED DISPOSITIVE POWER

  See response to Row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  1,080,546 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  2.0% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  PN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS.

  New Leaf Venture Management III, L.L.C.

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

Number of

Shares

 Beneficially 

Owned by

Each

Reporting

Person

With

  SOLE VOTING POWER

1,080,546 shares, all of which are directly owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote all of the shares directly owned by NLV III, and (c) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote all of such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

1,080,546 shares, all of which are directly owned by NLV III, except that (a) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares, (b) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of the shares directly owned by NLV III, and (c) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of all of such shares.

  SHARED DISPOSITIVE POWER

  See response to row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  1,080,546 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  2.0% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  OO

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS

  New Leaf Biopharma Opportunities II, L.P. (“Biopharma II”)

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

NUMBER OF

SHARES

 BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

  SOLE VOTING POWER

208,975 shares, except that (a) New Leaf BPO Associates II, L.P. (“NLBA II”), the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) New Leaf BPO Management II, L.L.C. (“NLB Management II”), the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

208,975 shares, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

  SHARED DISPOSITIVE POWER

  See response to row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  208,975 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  0.4% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  PN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS

  New Leaf BPO Associates II, L.P.

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

NUMBER OF

SHARES

 BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

  SOLE VOTING POWER

208,975 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

208,975 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

  SHARED DISPOSITIVE POWER

  See response to row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  208,975 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  0.4% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  PN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS

  New Leaf BPO Management II, L.L.C.

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  Delaware

NUMBER OF

SHARES

 BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

  SOLE VOTING POWER

208,975 shares, all of which are owned by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to vote such shares.

  SHARED VOTING POWER

  See response to row 5.

  SOLE DISPOSITIVE POWER

208,975 shares, all of which are owned by Biopharma II, except that (a) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, (b) NLB Management II, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares, and (c) each of Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares.

  SHARED DISPOSITIVE POWER

  See response to row 7.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  208,975 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  0.4% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  OO

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS

  Ronald M. Hunt

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  United States citizen

NUMBER OF

SHARES

 BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

  SOLE VOTING POWER

See response to row 6.

  SHARED VOTING POWER

1,289,521 shares, of which (a) 1,080,546 are owned directly by NLV III and (b) 208,975 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares directly owned by NLV III, (v) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares owned by NLV III, and (vi) Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to vote such shares owned by Biopharma II.

  SOLE DISPOSITIVE POWER

  See response to row 8.

  SHARED DISPOSITIVE POWER

1,289,521 shares, of which (a) 1,080,546 are owned directly by NLV III and (b) 208,975 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares directly owned by NLV III, (v) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares owned by NLV III, and (vi) Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares owned by Biopharma II.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  1,289,521 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  2.4% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  IN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

  NAMES OF REPORTING PERSONS

  Vijay K. Lathi

  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)

  (a)  ☐        (b)  ☒

  SEC USE ONLY

  CITIZENSHIP OR PLACE OF ORGANIZATION

  United States citizen

NUMBER OF

SHARES

 BENEFICIALLY 

OWNED BY

EACH

REPORTING

PERSON

WITH

  SOLE VOTING POWER

  See response to row 6.

  SHARED VOTING POWER

1,289,521 shares, of which (a) 1,080,546 are owned directly by NLV III and (b) 208,975 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to vote such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to vote such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to vote such shares directly owned by NLV III, (v) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to vote such shares owned by NLV III, and (vi) Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to vote such shares owned by Biopharma II.

  SOLE DISPOSITIVE POWER

  See response to row 8.

  SHARED DISPOSITIVE POWER

1,289,521 shares, of which (a) 1,080,546 are owned directly by NLV III and (b) 208,975 are owned directly by Biopharma II, except that (i) NLBA II, the sole general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (ii) NLV Associates III, the sole general partner of NLV III, may be deemed to have sole power to dispose of such shares owned by NLV III, (iii) NLB Management III, the sole general partner of NLBA II and ultimate general partner of Biopharma II, may be deemed to have sole power to dispose of such shares owned by Biopharma II, (iv) NLV Management III, the sole general partner of NLV Associates III and ultimate general partner of NLV III, may be deemed to have sole power to dispose of such shares directly owned by NLV III, (v) Hunt and Lathi, the managers of NLV Management III, may each be deemed to have shared power to dispose of such shares owned by NLV III, and (vi) Hunt and Lathi, the managers of NLB Management II, may each be deemed to have shared power to dispose of such shares owned by Biopharma II.

  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

  1,289,521 shares

  CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

  ☐

  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

  2.4% ⁽¹⁾

  TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

  IN

Based on 52,871,645 shares of the Issuer’s Common Stock outstanding as of November 1, 2021, as reported by the Issuer in the Form 10-Q.

Amount beneficially owned:

Percent of class:

Number of shares as to which the person has:

Sole power to vote or to direct the vote: see line 5 of cover sheets.*

Shared power to vote or to direct the vote: see line 6 of cover sheets.*

Sole power to dispose or to direct the disposition of: see line 7 of cover sheets*

Shared power to dispose or to direct the disposition of: see line 8 of cover sheets.*

Each Reporting Person disclaims beneficial ownership of such shares of Common Stock, except for the shares, if any, such Reporting Person holds of record and to the extent of their pecuniary interest therein, if any.

/s/ Craig L. Slutzkin

/s/ Craig L. Slutzkin

/s/ Craig L. Slutzkin

/s/ Craig L. Slutzkin

/s/ Craig L. Slutzkin

/s/ Craig L. Slutzkin

*

*

This Schedule 13G was executed by Craig L. Slutzkin on behalf of the individuals listed above pursuant to Powers of Attorney. Note that copies of the applicable Powers of Attorney are already on file with the appropriate agencies.