0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Changes in Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Changes in Stockholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Nature of Business and Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Research Collaboration and License Agreements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Marketable Securities and Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Property, Equipment and Leasehold Improvements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Right of Use Assets and Liabilities link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Accounts Payable and Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Long-Term Debt link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Equity link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Equity Method Investments link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Research Collaboration and License Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Marketable Securities and Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Property, Equipment and Leasehold Improvements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Right of Use Assets and Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Accounts Payable and Accrued Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Long-Term Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Nature of Business and Basis of Presentation (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Summary of Significant Accounting Policies - Cash Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Research Collaboration and License Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Research Collaboration and License Agreements - Summary of Contract Balances (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Research Collaboration and License Agreements - Transaction Price Allocated to Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Research Collaboration and License Agreements - Transaction Price Allocated to Performance Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Marketable Securities and Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Property, Equipment and Leasehold Improvements - Schedule of Property, Equipment and Leasehold Improvements (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Property, Equipment and Leasehold Improvements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Right of Use Assets and Liabilities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Right of Use Assets and Liabilities - Components of Lease Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Right of Use Assets and Liabilities - Schedule of Supplemental Cash Flow Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Right of Use Assets and Liabilities - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Right of Use Assets and Liabilities - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Accounts Payable and Accrued Liabilities - Components of Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Long-Term Debt - Schedule of Long Term Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Long-Term Debt - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Long-Term Debt - Schedule of Anticipated Future Minimum Payments on Long-Term Debt Excluding Discount on Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Equity - Schedule of Assumptions Used to Determine Fair Value of and Stock Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Equity - Summary of Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Equity - Summary of Restricted Stock Grant Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Equity Method Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Income Taxes - Income Tax Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Income Taxes - Reconciliation of the U.S. Federal Statutory Income Tax Rate to Effective Income Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Income Taxes - Summary of Deferred Income Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Income Taxes - Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Net Loss Per Share - Basic and Diluted Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Net Loss Per Share - Securities Excluded from the Computations of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Segment Information - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Segment Information - Financial Information (Details) link:presentationLink link:calculationLink link:definitionLink